The Smith & Wesson 645 Series is a model of handgun introduced in 1985. Smith & Wesson (S&W) began experiments with .45 ACP-firing pistols in 1984, and produced their first one, the Model 645, in 1985. Public demand led to the development of this series. The series is basically a .45 ACP version of their 9mm Parabellum weapons. They are normally double-action weapons. They generally have a coned muzzle instead of a separate barrel bushing. Like many Smith & Wesson models, each variant was generally in production for only a few years.
The Model 645 was introduced in 1985, and produced until 1988. It has a stainless steel frame and slide, an ambidextrous safety/decocker, a squared trigger guard, and black plastic grip plates. The Model 745, built from 1986-1990, was a single-action target version of the Model 645, with a match barrel, Novak sight (an adjustable rear sight was optional), an adjustable trigger stop, and walnut grip plates. It does not have ambidextrous controls, but does have a half-cock safety.
When Smith & Wesson changed its numbering system, one of the first in this series was the 4505; this is essentially the 645 with only the safety catch ambidextrous and a blued finish. A Novak Lo-Mount rear sight was installed on a small number of 4505s. It was produced only in 1991. The 4506, has stainless steel finish, a Novak Lo-Mount rear sight, and a Xenoy wrap-around grip. After 1998, the 4506 had a squared trigger guard. It was produced from 1988-2001. The 4505 and 4506 are a bit heavier than the 645, and both are identical for game purposes.
The S&W 645 was purportedly used in Miami Vice by the character Vice Detective Sonny Crockett in seasons 3 and 4 of the TV series.
| USA In The Waistband IWB Leather Belt Loop High Ride Holster CCW Choose Gun 6 | |
 |
$69.95 Time Remaining: 2d 21h 6m Buy It Now for only: $69.95 |
| Safariland I94 holster for SW 645 suede leather + 2 Mag Holders | |
 |
$21.00 Time Remaining: 5d 10h 59m |
| Don Hume H718 no 10 5 for SW 645 | |
 |
$30.00 Time Remaining: 5d 14h 29m |
| SOB Small Of the Back Leather Holster Fits Smith Wesson Model 645 | |
 |
$31.19 Time Remaining: 6d 12h 49m Buy It Now for only: $31.19 |
| S W 645 GUN HOLSTER NEW LAW ENFORCEMENT SECURITYW FREE FOLDING KNIFE 301 | |
 |
$9.99 Time Remaining: 6d 13h 56m Buy It Now for only: $9.99 |
| Safariland SW Smith Wesson 645 89V J86 Black Leather Holder | |
 |
$11.99 Time Remaining: 6d 17h 56m Buy It Now for only: $11.99 |
| ANKLE Concealment GUN Holster S W 645LEFT LAW ENFORCEMENT SECURITY704L | |
 |
$16.09 Time Remaining: 6d 19h 7m Buy It Now for only: $16.09 |
| Shoulder Gun Holster Left Hand Draw SW 645 W Free Trigger Lock 204 L | |
 |
$16.09 Time Remaining: 6d 19h 7m Buy It Now for only: $16.09 |
| ANKLE GUN HOLSTER RHSW 64510064506GLOCK 1722SIG 220226RUGAR P704R | |
 |
$16.09 Time Remaining: 6d 19h 8m Buy It Now for only: $16.09 |
| S W 645 GUN HOLSTER NEW SECURITY W FREE TRIGGER LOCK 301 | |
 |
$14.29 Time Remaining: 6d 19h 34m Buy It Now for only: $14.29 |
| Safariland 0705 Low Ride 15in Drop Level III Retention SW 645 0705 23 92 | |
 |
$155.74 Time Remaining: 6d 22h 36m Buy It Now for only: $155.74 |
| USA Premium In The Waistband IWB Leather Belt Loop Mag Clip Pouch Choose Gun 6 | |
 |
$44.95 Time Remaining: 7d 20h 12m Buy It Now for only: $44.95 |
| Gun Holster BUY 1 SHOULDER GET 1 HIP FREE Glock 17 22 S W 4506 645 S4H4 | |
 |
$21.95 Time Remaining: 8d 13h 47m Buy It Now for only: $21.95 |
| Gun Holster ANKLE holster Style Fits Glock 17 22 Smith Wesson 4506 645 A4 | |
 |
$14.95 Time Remaining: 8d 15h 7m Buy It Now for only: $14.95 |
| SWEET Vintage Tex Shoemaker Brown Leather OWB Paddle Holster For S | |
 |
$87.00 Time Remaining: 9d 5h 15m Buy It Now for only: $87.00 |
| Gun holster for Smith Wesson 645 With 5 Barrel | |
 |
$19.95 Time Remaining: 9d 11h 1m Buy It Now for only: $19.95 |
| Bucheimer leather holster SW 645 Ugly patent leather 2 1 4 belt loop RH | |
 |
$22.95 Time Remaining: 9d 14h 7m Buy It Now for only: $22.95 |
| Vintage Cast Metal Dummy Guns For SW Used By Tex Shoemaker Holster Making 2 | |
 |
$65.00 Time Remaining: 9d 14h 12m Buy It Now for only: $65.00 |
| Gun Shoulder Holster for SW 64510064506DBL POUCH VERTICAL CARRY | |
 |
$25.71 Time Remaining: 12d 10h 29m Buy It Now for only: $25.71 |
| USA Holsters IWB Inside Waist Gun Magazine Clip Mag Pouch ForSelect Model 6 | |
 |
$39.95 Time Remaining: 14d 8h 37m Buy It Now for only: $39.95 |